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. 2015 Mar 11;16(3):5555–5571. doi: 10.3390/ijms16035555

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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PEA reduces the 4-aminopyridine-induced increase in cytosolic Ca²⁺ concentration ([Ca²⁺]_C) but fails to alter the synaptosomal membrane potential. The [Ca²⁺]_C (nM) (A) or synaptosomal membrane potential (B) was measured in the absence (control) and in the presence of 5 μM PEA, added 10 min before depolarization with 1 mM 4-aminopyridine. (C) Inhibition of KCl (15 mM)-evoked glutamate release by PEA. Results are mean ± SEM of 5 independent experiments. ** p < 0.01, *** p < 0.001 versus control group.