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. 2015 Mar 11;16(3):5555–5571. doi: 10.3390/ijms16035555

Figure 4.

Figure 4

Blockade of Cav2.1 (P/Q-type) channels prevents the inhibitory effect of PEA on 4-aminopyridine-evoked glutamate release. Bar graph showing glutamate release induced by 1 mM 4-aminopyridine in the absence (control) or presence of 5 μM PEA, 2 μM ω-conotoxin GVIA, 2 μM ω-conotoxin GVIA and 5 μM PEA, 500 nM ω-agatoxin IVA, 500 nM ω-agatoxin IVA and 5 μM PEA, 50 μM dantrolene, 50 μM dantrolene and 5 μM PEA, 100 μM CGP37157, or 100 μM CGP37157 and 5 μM PEA. PEA was added 10 min before depolarization, whereas the other drugs were added 30 min before depolarization. Results are mean ± SEM of 5–6 independent experiments. ** p < 0.01, *** p < 0.001 versus control group. # p < 0.05 versus the ω-conotoxin GVIA-, dantrolene- or CGP37157-treated group.