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. 2015 Mar 11;16(3):5555–5571. doi: 10.3390/ijms16035555

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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PEA-mediated inhibition of evoked glutamate release is prevented by the PKA inhibitor H89. Bar graph showing glutamate release induced by 1 mM 4-aminopyridine in the absence (control) or presence of 5 μM PEA, 50 μM PD98059, 50 μM PD98059 and 5 μM PEA; 10 μM GF109203X, 10 μM GF109203X and 5 μM PEA; 100 μM H89; or 100 μM H89 and 5 μM PEA. PEA was added 10 min before depolarization, whereas the other drugs were added 30 min before depolarization. Results are mean ± SEM of 5–7 independent experiments. *** p < 0.001 versus control group. ^# p < 0.05 versus the PD98059- or GF109203X-treated group.