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Clinical trials with BRAF inhibitors in patients with thyroid cancer.
| Drug | Thyroid Cancer | Responses | Authors | |||
|---|---|---|---|---|---|---|
| PR | SD | PD | PFS (months) | |||
| Dabrafenib | 14 DeTC | 21% | – | – | – | Falchook et al. [123] |
| Selumetinib | 2 DeTC | – | 100% 19 cycles | – | – | Adjei et al. [127] |
| Selumetinib | 39 DeTC | 3% | 54% | 28% | 8 | Hayes et al. [128] |
Dedifferentiated thyroid cancer (DeTC); partial response (PR); progressive disease (PD); progression-free survival (PFS); stable disease (SD).
