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Down-regulation of incretin receptors in pancreatic β-cells under diabetic conditions. Under diabetic conditions, expression of incretin receptors (GLP-1 and GIP receptors) in β-cells are down-regulated, leading to decrease of insulin secretion, increase of β-cell apoptosis and decrease of β-cell growth. Therefore, it is likely that down-regulation of incretin receptor expression is involved in β-cell glucose toxicity found in type 2 diabetes.
