Table 1. Selected Characteristics of African American and Nonblack Patients With Chronic Lymphocytic Leukemia at Initial Presentation.
Characteristic | No. of Patients (%) | ||
---|---|---|---|
|
|||
AA, n = 84 | NB, n = 1571 | P | |
Age: Median [range], y | 59 [35-88] | 59 [26-94] | .56 |
Sex, men:women | 48:36 | 955:616 | .57 |
Diagnosis, CLL:SLL | 75:9 | 1331:240 | .35 |
Hemoglobin: Median [range], g/dL | 12.9 [7-16.5] | 13.7 [5.5-17.7] | .001 |
WBC count: Median [range], ×103/μL | 21.6 [4.4-421.4] | 22.1 [1-786] | .42 |
Absolute lymphocyte count: Median [range], ×103/μL | 16.27 [0.55-331.54] | 16.51 [0-707.40] | .38 |
Platelets: Median [range], ×103/μL | 215 [29-631] | 200 [3-961] | .53 |
Hepatomegaly | 2 (2) | 80 (5) | .27 |
Splenomegaly | 8 (10) | 215 (14) | .28 |
Bulky lymphadenopathy: ≥5 cm | 8 (10) | 22 (1) | <.0001 |
Rai stage | .02 | ||
0 | 18 (21) | 508 (32) | |
1 | 48 (57) | 718 (46) | |
2 | 6 (7) | 183 (12) | |
3 | 8 (10) | 67 (4) | |
4 | 4 (5) | 95 (6) | |
Constitutional symptoms | 23 (27) | 155 (10) | <.0001 |
β2-Microglobulin: Median [range], mg/L | 2.7 [1.2-11.9] | 2.4 [0-36.6] | .004 |
Unmutated IGHV | 44/68 (65) | 587/1251 (47) | .006 |
CD38 positive | 27/78 (35) | 363/1214 (30) | .38 |
ZAP70 positive | 48/74 (65) | 495/1041 (47) | .004 |
Cytogenetic abnormality (FISH) | .0004 | ||
del17p | 6/75 (8) | 84/1406 (6) | |
del11q | 15/75 (20) | 155/1406 (11) | |
del13q | 13/75 (17) | 527/1406 (37) | |
Trisomy 12 | 23/75 (31) | 246/1406 (17) | |
Negative | 18/75 (24) | 393/1406 (28) | |
First-line chemoimmunotherapy, no. (%) | 39/43 (91) | 431/487 (88) | .81 |
Abbreviations: AA, African American; CLL, chronic lymphocytic leukemia; IGHV, immunoglobulin heavy chain variable region; NB, nonblack; SLL, small lymphocytic lymphoma; ZAP80, ζ-chain–associated protein kinase 70.