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. Author manuscript; available in PMC: 2015 Apr 13.
Published in final edited form as: Cancer. 2013 Jul 8;119(17):3177–3185. doi: 10.1002/cncr.28030

Table 1. Selected Characteristics of African American and Nonblack Patients With Chronic Lymphocytic Leukemia at Initial Presentation.

Characteristic No. of Patients (%)

AA, n = 84 NB, n = 1571 P
Age: Median [range], y 59 [35-88] 59 [26-94] .56
Sex, men:women 48:36 955:616 .57
Diagnosis, CLL:SLL 75:9 1331:240 .35
Hemoglobin: Median [range], g/dL 12.9 [7-16.5] 13.7 [5.5-17.7] .001
WBC count: Median [range], ×103/μL 21.6 [4.4-421.4] 22.1 [1-786] .42
Absolute lymphocyte count: Median [range], ×103/μL 16.27 [0.55-331.54] 16.51 [0-707.40] .38
Platelets: Median [range], ×103/μL 215 [29-631] 200 [3-961] .53
Hepatomegaly 2 (2) 80 (5) .27
Splenomegaly 8 (10) 215 (14) .28
Bulky lymphadenopathy: ≥5 cm 8 (10) 22 (1) <.0001
Rai stage .02
 0 18 (21) 508 (32)
 1 48 (57) 718 (46)
 2 6 (7) 183 (12)
 3 8 (10) 67 (4)
 4 4 (5) 95 (6)
Constitutional symptoms 23 (27) 155 (10) <.0001
β2-Microglobulin: Median [range], mg/L 2.7 [1.2-11.9] 2.4 [0-36.6] .004
Unmutated IGHV 44/68 (65) 587/1251 (47) .006
CD38 positive 27/78 (35) 363/1214 (30) .38
ZAP70 positive 48/74 (65) 495/1041 (47) .004
Cytogenetic abnormality (FISH) .0004
 del17p 6/75 (8) 84/1406 (6)
 del11q 15/75 (20) 155/1406 (11)
 del13q 13/75 (17) 527/1406 (37)
 Trisomy 12 23/75 (31) 246/1406 (17)
 Negative 18/75 (24) 393/1406 (28)
First-line chemoimmunotherapy, no. (%) 39/43 (91) 431/487 (88) .81

Abbreviations: AA, African American; CLL, chronic lymphocytic leukemia; IGHV, immunoglobulin heavy chain variable region; NB, nonblack; SLL, small lymphocytic lymphoma; ZAP80, ζ-chain–associated protein kinase 70.