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. 2015 Mar 18;4(3):e00021. doi: 10.1002/psp4.21

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© 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Preliminary patient education tool application. Shown are screenshots of the application featuring a one-compartment first-order absorption model running in a browser-window. The concentration–time profile is depicted as the solid red line, and black horizontal dashed lines represent the hypothetical therapeutic window (drug is ineffective at less than 2.5 mg/L, and toxic when greater than 5 mg/L). Top: Upon application initiation, the “Dose Frequency” selection box is pre-set to once daily and the output plot displays the concentration–time profile for the hypothetical drug over 10 d (10 doses) accordingly. Bottom: A scenario where the twice-daily dosing regimen is selected. The plot automatically updates to show the concentration–time profile when 20 doses are administered within the same 10-d period. The “missed dose” and “double dose” checkboxes also automatically update to describe specific doses in the twice-daily regimen.