Table 2.
Shiny versus NONMEM® + R processing: comparisona of run times
| Methodb | IV loading-bolus-bolus (20–10-10 mg/kg) (seconds) | IV loading-continuous infusion (16–24 mg/kg) (seconds) |
|---|---|---|
| NONMEM® + R Processingc | ≈ 385 | ≈ 366 |
| Shiny: one core | ≈ 103 | ≈ 60 |
| Shiny: four cores, compiled functions | ≈ 35 | ≈ 27 |
a
Based on application Example 3 with n = 1,000 and evaluations at 15-min intervals over 72 h.
b
Simulations were performed using a Dell® Power Edge R910 server with 4 x 10 core Xeon 2.26 GHz processors and 256 GB of RAM running Windows 8 Server SP1 64-bit.
c
NONMEM® Version VII Level 3.014 using the Wings for NONMEM (Version 734) interface (http://wfn.sourceforge.net/), with Intel® Visual Fortran Composer XE 2013 Update 1, and ADVAN8 subroutine.