Table 3.

Mathematical approaches to predict cardiac damage

Drug class	Analysis method	Endpoint	Conclusions
Cox2 inhibitors58	Multivariate odds ratios on use or not of drug	MI and cardiac death	Rofecoxib use increases the risk of serious coronary heart disease compared with celecoxib use. Naproxen use does not protect against serious coronary heart disease
Hormone replacement therapy59	Logistic regression	Venous thromboembolism	Current use of hormone replacement therapy was associated with a higher risk of venous thromboembolism, although the risk seemed to be restricted to the first year of use.
Bendectin and others60	Pairwise comparison on mothers use of drug during pregnancy	Congenital Heart Disease	In particular, aspirin use in early pregnancy was associated with about a twofold increase in the frequency of defects in septation of the truncus arteriosus
Cox2 inhibitors61	Proportional hazards on use and high/low dose	MI	Rofecoxib significant effect. Aspirin reduces the effect
Appetite suppressants62	Pairwise comparison vs. control and frequency of event vs. drug use	Cardiac valve regurgitation	Significant effects for some of the drugs considered
Dopamine agonists63	Pairwise comparison of risk	Cardiac valve regurgitation	Significant effects for some drugs
Third generation oral contraceptives64	Pairwise comparisons	Venous thromboembolism	Risk of venous thromboembolism was slightly increased in users of third generation oral contraceptives compared with users of second generation products.
ADHD drugs in children65	Cox hazard ratios	Serious cardiovascular events (sudden cardiac death, acute myocardial infarction, and stroke)	No significant effect though upper CI points to doubling of events

References contained in Supplementary Material. MI, myocardial infarction.