Skip to main content
. Author manuscript; available in PMC: 2015 Apr 13.
Published in final edited form as: Oncogene. 2005 Jan 20;24(4):616–626. doi: 10.1038/sj.onc.1208125

Figure 6.

Figure 6

Regulation of HO-1 activity by arsenite in melanoma cells: effects of inhibition of signal transduction pathways. (a) Effects of LY294002 (50 μM), PD98059 (50 μM), SP600125 (10 μM) and SB203580 (10 μM) on arsenite (10 μM)-induced HO-1 protein levelsin melanoma cells. (b) Surface EGFR levelswere determined by flow cytometry of stained FEMX and WM793 cells. Filled histogram represents nonspecific staining with mouse Ig-PE. (c) Western blot analysis of HO-1 levels from WM793 and FEMX cellsfollowing treatment with AG1478 (20 μM), arsenite (10 μM) or their combination