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. Author manuscript; available in PMC: 2015 Apr 13.
Published in final edited form as: Amyloid. 2010 Nov 10;17(0):118–128. doi: 10.3109/13506129.2010.530008

Figure 1.

Figure 1

EPR spectra and EM images of spin-labelled h-IAPP in the presence and absence of curcumin. EPR spectra of 16R1 h-IAPP aggregates formed after incubation with 0 μM (A), 1 μM (B), 10 μM (C) and 100 μM (D) curcumin. All spectra were obtained at a scan width of 150 Gauss and are rescaled to the same amplitude. The arrow in panel (D) denotes a hyperfine component that arises from strong immobilisation and loss of spin exchange that is caused by curcumin-dependent alteration of h-IAPP misfolding. Representative spectra from four independent experiments are shown. The corresponding EM images of 16R1 h-IAPP incubated with 0 μM (E), 1 μM (F), 10 μM (G) and 100 μM (H) curcumin are also shown.