Fig. 6.

CLR receptor structure and kinases. The structure of the extracellular domains of the CLR Dectin-1 (PDB ID 2CL8) are shown as ribbons colored blue (N terminus) to red (C terminus). The bound glycan is shown in space-filling atoms. The structure is extended by modeling the dimer of transmembrane helices (colored in rainbow colors and based on PDB ID 2HAC). In the lower panel representing the cytoplasm, the tyrosine kinase Syk recognizes hemITAM phospho-tyrosine motifs (phospho-Tyr atoms in gold) with its tandem SH2 domains (based on combining PDB IDs 4FL3 and 1A81 for the kinase (green) and SH2 domains (blue) respectively).