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Cleavage- and topology-based compartmentation of Adhesion GPCR architecture. Most Adhesion GPCRs undergo autoproteolysis at the GPS within their GAIN domain, resulting in a two-partite structure containing the NTF and the CTF (left). Alternatively, the protein layout of all Adhesion GPCRs is marked by a three-partite structure consisting of an ECD, a 7TM domain, and an ICD.
