Table 1.

Metabolic genes and SNPs included in maternal-fetal gene-gene interaction analysis

Gene symbol	Ref SNP	Chr a	Position	Alleles b	SNP information	MAFc (CEU)	Selection criteria
TCF7L2	rs12255372	10	114808902	G/T	Intron	0.21	Diabetes-associated
TCF7L2	rs7903146	10	114758349	C/T	Intron	0.22	Diabetes-associated
TCF7L2	rs290487	10	114909731	C/T	Intron	0.27	Diabetes-associated
TCF7L2	rs10885390	10	114640797	T/A	Intergenic	0.24	Diabetes-associated
TCF7L2	rs3814573	10	114898093	C/T	Intron	0.40	Diabetes-associated
UCP2	rs660339	11	73689104	G/A	Missense	0.43	Obesity/diabetes
ENPP1	rs1044498	6	132172368	A/C	Missense	0.31	Insulin resistance
FTO	rs9939609	16	53820527	T/A	Intron	0.38	Obesity, BMI
FTO	rs8050136	16	53816275	C/A	Intron	0.37	Obesity, BMI
FTO	rs1421085	16	53800954	T/C	Intron	0.26	Obesity, BMI
FTO	rs17817449	16	53813367	T/G	Intron	0.35	Obesity, BMI
ADRB3	rs4994	8	37823798	T/C	Missense	0.10	Obesity, BMI
PPARG	rs1801282	3	12393125	C/G	Intron	0.06	Obesity-associated
PPARGC1A	rs8192678	4	23815662	G/A	Missense	0.30	Obesity/metabolic disorders
PPARGC1A	rs3736265	4	23814707	G/A	Missense	0.11	Obesity/metabolic disorders
LEP	rs11760956	7	127891087	G/A	Intron	0.29	tagSNP
LEP	rs12706831	7	127887068	T/G	Intron	0.46	tagSNP
LEP	rs3828942	7	127894305	G/A	Intron	0.45	tagSNP
LEP	rs2071045	7	127892980	T/C	Intron	0.26	tagSNP
LEP	rs2167270	7	127881349	G/A	5′utr	0.35	tagSNP
SLC2A2	rs11924032	3	170735099	G/A	Intron	0.31	tagSNP
SLC2A2	rs6785233	3	170756985	T/G	Intergenic	0.19	tagSNP
SLC2A2	rs5400	3	170732300	C/T	Missense	0.21	Diabetes-associated, cholesterol levels

^aChr (Chromosome) Genomic Build 37.1; group term GRCh37

^bRefSNP alleles: reference allele/risk allele (minor allele)

^cMAF (Minor Allele Frequency) source: 1000 Genomes project