Table 3.

Top maternal-fetal metabolic gene-gene interactions associated with neural tube defects, National Birth Defects Prevention Study, 1999–2007

Maternal SNP	Fetal SNP	Interaction ORa	95% CIb	p-value	q-valuec	LRT p-value from step 2d,e
ENPP1 rs1044498	SLC2A2 rs6785233	3.65	2.32–5.74	2.09E-08	0.001	0.00004
LEP rs12706831	SLC2A2 rs6785233	0.45	0.29–0.71	0.0005	0.016	0.00001
ENPP1 rs1044498	SLC2A2 rs5400	1.98	1.34–2.92	0.0006	0.016	0.001
LEP rs2071045	SLC2A2 rs5400	0.50	0.32–0.77	0.0016	0.03	0.008
LEP rs2071045	SLC2A2 rs6785233	0.46	0.27–0.77	0.0029	0.04	0.06
LEP rs12706831	SLC2A2 rs5400	0.59	0.41–0.86	0.0059	0.08	NE
LEP rs11760956	SLC2A2 rs6785233	0.63	0.41–0.99	0.0450	0.44	NE
LEP rs3828942	SLC2A2 rs6785233	0.64	0.42–0.99	0.0473	0.44	NE

^aInteraction odds ratio (OR) from step 1 (case-only analysis)

^bConfidence interval (CI)

^cFalse discovery rate q-value

^dOnly interactions where q<0.05 in step 1 were confirmed in step 2 (log-linear analysis in case-parent triads)

^eNot estimated (NE)