. Author manuscript; available in PMC: 2015 Apr 13.

Published in final edited form as: Mol Genet Metab. 2013 Nov 18;111(1):46–51. doi: 10.1016/j.ymgme.2013.11.004

Table 4.

Top maternal-fetal metabolic gene-gene interactions in non-obese mothers associated with neural tube defects, National Birth Defects Prevention Study, 1999–2007

Maternal SNP	Fetal SNP	Interaction OR^a	95% CI^b	p-value
ENPP1 rs1044498	SLC2A2 rs6785233	3.24	1.83–5.74	5.18E-05
LEP rs12706831	SLC2A2 rs6785233	0.54	0.31–0.93	0.0027
ENPP1 rs1044498	SLC2A2 rs5400	1.78	1.12–2.86	0.0153
LEP rs2071045	SLC2A2 rs5400	0.58	0.37–0.91	0.0259
LEP rs2071045	SLC2A2rs6785233	0.49	0.27–0.88	0.0172
LEP rs12706831	SLC2A2 rs5400	0.58	0.37–0.91	0.0176
LEP rs11760956	SLC2A2 rs6785233	0.85	0.50–1.44	0.5506
LEP rs3828942	SLC2A2 rs6785233	0.72	0.43–1.25	0.2552

Interaction odds ratio (OR) from case-only analysis

Confidence interval (CI)