Table 1. Thermodynamic parameters of the Hsp90 N-terminal domain fitted from ITC experiments.

Protein	Ligand	N	Kd (μM)	ΔH (103 cal mol−1)	ΔS (cal mol−1 deg−1)
	AMPPCP	1.06 ± 0.02	3.80 ± 0.68	−1.40 ± 0.04	20.2
Hsp90N	AMPPNP	1.04 ± 0.03	7.93 ± 2.34	−3.12 ± 0.01	13.07
	ADP	1.03 ± 0.02	3.08 ± 0.34	−9.99 ± 0.22	−7.72