TABLE 1.
Resistance-associated variants revealed by 454 deep sequencing with frequency cutoff set at 0.5%
| Patient | Resistance-associated variants (%) ina: |
|||
|---|---|---|---|---|
| BL1 | EOT1 | BL2 | EOT2/3 | |
| 1 | V36A (0.9) | V36A (2.8) | V36A (0.6) | |
| V36M (22.6) | V36M (4.4) | |||
| T54A (1.8) | ||||
| R155K (31.0) | R155K (51.1) | |||
| R155T (3.9) | ||||
| V36A + R155K (1.6) | ||||
| V36M + R155K (15.3) | V36M + R155K (38.1) | |||
| V36M + R155T (1.1) | ||||
| T54A + R155K (1.0) | ||||
| 2 | V36A (0.8) | V36A (32.3) | V36A (0.8) | V36A (0.8)/V36A (25.8) |
| T54A (57.5) | ||||
| V36A+ T54A (4.5) | ||||
| 3 | V36M (6.7) | V36M (3.5) | ||
| R155K (5.6) | ||||
| R155G (0.6) | R155G (0.6) | |||
| V36M + R155K (0.7) | V36M + R155K (85.2) | V36M + R155K (92.4) | ||
| V36M + T54A + R155K (0.7) | ||||
| 4 | V36A (0.6) | |||
| V36M (25.6) | V36M (2.9) | |||
| T54A (0.6) | ||||
| T54S (4.6) | ||||
| R155K (5.7) | R155K (1.9) | |||
| R155T (1.9) | ||||
| V36A + R155K (0.6) | ||||
| V36M + T54S (1.1) | ||||
| V36M + R155K (37.7) | V36M + R155K (94.8) | |||
| V36M + R155T (4.4) | ||||
| T54S + R155K (10.9) | ||||
| T54S + R155T (0.7) | ||||
| V36M + T54S + R155K (1.7) | ||||
a
Variants in italics carry the same linked neutral mutation within a patient.