TABLE 2.
Activities of Debio1452 and comparator antimicrobial agents when tested against isolates of S. aureus
| Antimicrobial agent (no. tested) | MIC50 (μg/ml) | MIC90 (μg/ml) | Range (μg/ml) | % susceptible/% resistant according toa: |
|
|---|---|---|---|---|---|
| CLSI | EUCAST | ||||
| All S. aureus isolates (471) | |||||
| Debio1452 | 0.004 | 0.008 | 0.002 to 0.12 | −/− | −/− |
| Rifampin | 0.008 | 0.015 | 0.004 to >2 | 93.0/4.5 | −/− |
| Oxacillin | >2 | >2 | ≤0.25 to >2 | 34.2/65.8 | 34.2/65.8 |
| Erythromycin | >2 | >2 | ≤0.25 to >2 | 37.6/61.6 | 37.6/62.2 |
| Clindamycin | ≤0.25 | >2 | ≤0.25 to >2 | 72.0/27.6 | 71.5/28.0 |
| Daptomycin | 0.25 | 0.5 | ≤0.06 to 4 | 98.7/− | 98.7/1.3 |
| Vancomycin | 1 | 1 | ≤0.12 to 8 | 98.3/0.0 | 98.3/1.7 |
| Linezolid | 1 | 2 | 0.5 to >8 | 99.2/0.8 | 99.2/0.8 |
| Levofloxacin | 2 | >4 | ≤0.5 to >4 | 49.7/49.0 | 49.7/49.0 |
| Tetracycline | ≤2 | >8 | ≤2 to >8 | 83.4/15.7 | 82.0/17.0 |
| Trimethoprim-sulfamethoxazole | ≤0.5 | ≤0.5 | ≤0.5 to >2 | 93.0/7.0 | 93.0/6.6 |
| MSSA (154) | |||||
| Debio1452 | 0.004 | 0.03 | 0.002 to 0.12 | −/− | −/− |
| Rifampin | 0.008 | 0.008 | 0.004 to >2 | 98.1/0.6 | −/− |
| Oxacillin | ≤0.25 | ≤0.25 | ≤0.25 to 0.5 | 100.0/0.0 | 100.0/0.0 |
| Erythromycin | ≤0.25 | >4 | ≤0.25 to >4 | 77.3/22.1 | 77.3/22.1 |
| Clindamycin | ≤0.25 | ≤0.25 | ≤0.25 to >2 | 94.2/5.8 | 94.2/5.8 |
| Daptomycin | 0.25 | 0.5 | ≤0.06 to 1 | 100.0/− | 100.0/0.0 |
| Vancomycin | 1 | 1 | 0.25 to 2 | 100.0/0.0 | 100.0/0.0 |
| Linezolid | 1 | 1 | 0.5 to 2 | 100.0/0.0 | 100.0/0.0 |
| Levofloxacin | ≤0.5 | ≤0.5 | ≤0.5 to >4 | 92.2/7.1 | 92.2/7.1 |
| Tetracycline | ≤0.25 | 2 | ≤0.25 to >8 | 90.3/8.4 | 89.6/9.7 |
| Trimethoprim-sulfamethoxazole | ≤0.5 | ≤0.5 | ≤0.5 to >4 | 98.7/1.3 | 98.7/1.3 |
| MRSA (163) | |||||
| Debio1452 | 0.004 | 0.008 | 0.002 to 0.015 | −/− | −/− |
| Rifampin | 0.008 | 0.015 | 0.004 to >2 | 92.0/6.7 | −/− |
| Oxacillin | >2 | >2 | >2 | 0.0/100.0 | 0.0/100.0 |
| Erythromycin | >4 | >4 | ≤0.25 to >4 | 18.4/79.8 | 18.4/81.6 |
| Clindamycin | >2 | >2 | ≤0.25 to >2 | 47.9/52.1 | 47.9/52.1 |
| Daptomycin | 0.25 | 0.5 | 0.12 to 1 | 100.0/− | 100.0/0.0 |
| Vancomycin | 1 | 1 | 0.5 to 2 | 100.0/0.0 | 100.0/0.0 |
| Linezolid | 1 | 1 | 0.5 to 2 | 100.0/0.0 | 100.0/0.0 |
| Levofloxacin | >4 | >4 | ≤0.5 to >4 | 19.6/77.3 | 19.6/77.3 |
| Tetracycline | ≤0.25 | >8 | ≤0.25 to >8 | 81.6/17.2 | 79.1/18.4 |
| Trimethoprim-sulfamethoxazole | ≤0.5 | ≤0.5 | ≤0.5 to >4 | 93.3/6.7 | 93.3/5.5 |
| Molecularly characterized S. aureus (154) | |||||
| Debio1452 | 0.004 | 0.008 | 0.002 to 0.12 | −/− | −/− |
| Rifampin | 0.008 | 2 | 0.004 to >2 | 89.0/5.8 | −/− |
| Oxacillin | >2 | >2 | ≤0.25 to >2 | 4.5/95.5 | 4.5/95.5 |
| Erythromycin | >2 | >2 | ≤0.25 to >2 | 18.2/81.8 | 18.2/81.8 |
| Clindamycin | ≤0.25 | >2 | ≤0.25 to >2 | 75.3/23.4 | 74.0/24.7 |
| Daptomycin | 0.5 | 0.5 | 0.25 to 4 | 96.1/− | 96.1/3.9 |
| Vancomycin | 1 | 1 | ≤0.12 to 8 | 94.8/0.0 | 94.8/5.2 |
| Linezolid | 1 | 2 | 0.5 to >8 | 97.4/2.6 | 97.4/2.6 |
| Levofloxacin | 4 | >4 | ≤0.5 to >4 | 39.0/61.0 | 39.0/61.0 |
| Tetracycline | ≤2 | >8 | ≤2 to >8 | 78.6/21.4 | 77.3/22.7 |
| Trimethoprim-sulfamethoxazole | ≤0.5 | >2 | ≤0.5 to >2 | 87.0/13.0 | 87.0/13.0 |