TABLE 3.
Activities of Debio1452 and comparator antimicrobial agents when tested against 103 isolates of coagulase-negative staphylococcia
| Antimicrobial agent used | MIC50 (μg/ml) | MIC90 (μg/ml) | Range (μg/ml) | % susceptible/% resistant according tob: |
|
|---|---|---|---|---|---|
| CLSI | EUCAST | ||||
| Debio1452 | 0.015 | 0.12 | 0.004 to 0.5 | −/− | −/− |
| Rifampin | 0.008 | 0.015 | ≤0.001 to >2 | 97.1/2.9 | −/− |
| Oxacillin | ≤0.25 | 1 | ≤0.25 to >2 | 83.5/16.5 | 83.5/16.5 |
| Erythromycin | ≤0.25 | >2 | ≤0.25 to >2 | 51.5/48.5 | 51.5/48.5 |
| Clindamycin | ≤0.25 | >2 | ≤0.25 to >2 | 88.3/11.7 | 85.4/11.7 |
| Daptomycin | 0.25 | 0.5 | ≤0.06 to 1 | 100.0/− | 100.0/0.0 |
| Vancomycin | 1 | 2 | 0.25 to 2 | 100.0/0.0 | 100.0/0.0 |
| Linezolid | 0.5 | 1 | ≤0.12 to 1 | 100.0/0.0 | 100.0/0.0 |
| Levofloxacin | ≤0.5 | >4 | ≤0.5 to >4 | 76.7/22.3 | 76.7/22.3 |
| Tetracycline | ≤2 | >8 | ≤2 to >8 | 86.3/12.7 | 82.4/13.7 |
| Trimethoprim-sulfamethoxazole | ≤0.5 | >2 | ≤0.5 to >2 | 86.4/13.6 | 86.4/10.7 |
a
Includes S. epidermidis (56 strains), S. haemolyticus (20 strains), S. hominis (11 strains), S. saprophyticus (6 strains), S. warneri (5 strains), and S. xylosus (5 strains).