End-of-study DAP MICs grouped by patterns of mutation in genes that contribute to the DNS phenotype. Whiskers are the interquartile ranges, and the dashed line is the median for each group. Groups, left to right, comprise MICs for strains with the wild-type mprF sequence (n = 5), an mprF mutation only (n = 7), mprF and rpoBC mutations only (n = 3), or an mprF mutation and at least one additional mutation in either cls2 or yycFG (n = 10). ∗, P < 0.05 versus the results for the wild type; ∗∗, P < 0.001 versus the results for the wild type (Mann Whitney test).