FIG 3.

Biological model of the contributions of genetic mutations and phenotypic adaptations to the development of daptomycin-nonsusceptible Staphylococcus aureus. Genes in which mutations emerged following treatment-dependent exposure conditions in the current study are represented by dark circles, and light-gray circles indicate wild-type sequences. Implications of mutations for the downstream elements (regulated gene or phenotype) are indicated by a plus or minus sign in the pathway. SXT, trimethoprim-sulfamethoxazole.