FIG 1.

Dose-dependent activities of 2-APB and chloroquine (CQ) on P. falciparum synchronized cultures of CQ-resistant K-1 strain. Shown are various concentrations of 2-APB (A) and CQ plus DMSO as solvent control (dashed line) and CQ plus 50 μM 2-APB (solid line) (B). The statistical significance of the differences between the treatments was assessed with Student's t test. **, P < 0.004, and ***, P < 0.0005. The results are presented as the mean ± SD from three independent experiments. RFU denotes relative fluorescence units in SYBR green I assay (see Materials and Methods).