FIG 2.

In vivo activities of chloroquine (CQ) and 2-APB on CQ-resistant P. chabaudi AS(30CQ) strain (A), and the potential of 2-APB in reversing CQ resistance (B). The antimalarial activity of each experimental group is shown as the ratio of parasitemia relative to the control (DMSO in panel A and CQ 3 mg/kg in panel B). (B) CQ plus 2-APB and CQ plus verapamil (VP) represent 3 mg/kg CQ plus 0.1 mg/kg 2-APB and 3 mg/kg CQ plus 20 mg/kg VP, respectively. The statistical significance of the differences between the groups (n = 3) was assessed with one-way analysis of variance (ANOVA), followed by Dunnett's test. ***, P < 0.0001 versus the control group.