TABLE 4.
MICs of ceftaroline alone or in combination with avibactam determined in 7H9sBa against clinical isolates of M. abscessus subsp. abscessus and M. abscessus subsp. bolletii
| Isolate | Subspecies | Colony morphotypeb | MIC (μg/ml)c |
|
|---|---|---|---|---|
| Ceftaroline | Ceftaroline + avibactam | |||
| 1 | abscessus | S | 4 | 0.5 |
| 2 | abscessus | R | 64 | 2 |
| 3 | abscessus | S | 4 | 0.5 |
| 4 | abscessus | S | 4 | 1 |
| 5 | abscessus | S | 4 | 0.5 |
| 6 | abscessus | R | 16 | 1 |
| 7 | abscessus | R | 8 | 2 |
| 8 | abscessus | R | 16 | 2 |
| 9 | bolletii | S | 2 | 1 |
| 10 | bolletii | R | 8 | 2 |
a
7H9sB, Middlebrook 7H9 medium supplemented with 0.05% (vol/vol) Tween 80 and 10% (vol/vol) oleic acid, albumin, dextrose, and catalase.
b
S, smooth morphotype; R, rough morphotype.
c
Data are the median results from three independent experiments. Avibactam was used at 4 μg/ml.