TABLE 3.
MICs of drugs for mecA-positive parent and passaged mutant strains
| Strain | MIC (μg/ml) ofa: |
||||||
|---|---|---|---|---|---|---|---|
| NAF | AMP | CFZ | CXT | CTX | CPT | BPR | |
| COLn | 256 | 16 | >256 | >256 | >256 | 1 | 2 |
| COLnex | 1 | 0.5 | 1 | 4 | 4 | <0.25 | 1 |
| COLnex(pAW8) | 0.5 | <0.25 | 0.5 | 4 | 4 | <0.25 | 1 |
| COLnex(pYK20) | 128 | 8 | 256 | 256 | >265 | 1 | 0.5 |
| COLnexpT(pYK20COLT*) | 128 | 64 | >256 | 8 | >256 | 64 | 32 |
| COLnexpB(pYK20COLB*) | >256 | 128 | >256 | >256 | >256 | 64 | 64 |
| SF8300 | 32 | 128 | 32 | 64 | 128 | 1 | 1 |
| SF8300ex | 0.5 | <0.25 | 1 | 4 | 4 | <0.25 | 0.5 |
| SF8300ex(pAW8) | <0.25 | <0.25 | 0.5 | 4 | 4 | <0.25 | 0.5 |
| SF8300ex(pYK20) | 32 | 8 | 128 | 128 | >256 | 0.5 | 1 |
| SF8300pT(pYK208300T*) | 128 | 16 | 128 | 128 | 256 | 4 | 4 |
a
NAF, nafcillin; AMP, ampicillin; CFZ, cefazolin; CXT, cefoxitin; CTX, ceftriaxone; CPT, ceftaroline; BRP, ceftobiprole.