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The release of MMP-2 (A), MMP-9 (B), and TIMP-1 (C) into pooled media, when GSNO (0–100 nM) was supplemented to HA-SMC cultures, in the presence or absence of EC cocultures. Data shown represent mean±standard error of protein synthesis after 21 days of culture, normalized to cell count within respective cases (n=3 per condition). *p<0.05 compared with GSNO-free cultures; #p<0.01 for no cocultures versus EC coculture, at a given GSNO dosage.
