FIG. 6.
Vascular contractility of HF-MSC and BM-MSC-based vascular constructs. HF-MSCs and BM-MSCs were embedded in fibrin hydrogels and cultured around mandrels (4.75-mm diameter) for 2 weeks forming cylindrical rings. Vascular contractility (Pa) was measured in the presence of ET-1 (20 nM), U46619 (10−6M), and KCl (118 mM). (a) BM-MSC-based TEVs; (b) HF-MSC-based TEVs. Statistical significance (*p<0.05) is denoted by bars between indicated samples. ET-1, Endothelin-1; KCl, potassium chloride; TEV, tissue-engineered vessel.