FIG. 6.

Transplantation of mRPC/PCL scaffold constructs into the subretinal space of Rho^−/− mice. (a-c) The same eye transplanted with the mRPC/PCL scaffold construct. Retinal picture (a) and SD-OCT (b, c) were examined 1 week after transplantation. (b): The fundus picture with indicated orientation of cross-sectional SD-OCT scan. The scanning line was shown in green. (c): The corresponding B-scan at the implantation site of the construct to (b). (d–q) Representative images of the samples collected 3 weeks after transplantation. (d) Three weeks after transplantation, cells migrated to different layers of the host retina. (e) An integrated rhodopsin-positive cell spread process (arrow). (f–k) An integrated recoverin-positive cell made contact with the residual PKC-positive cell (arrow, inset). (l–q) An integrated recoverin-positive cell expressed the synapse marker synaptophysin (arrow, inset). Arrow head indicated the PCL scaffold. Scale bar: 30 μm. SD-OCT, spectral domain optical coherence tomography. Color images available online at www.liebertpub.com/tea