Table 3. Changes in the Incidence, Patient Characteristics, Resource Utilization and Outcomes of Hospitalizations With Pregnancy-Associated Severe Sepsis .
| Variable | 2001 - 2002 (n = 113) | 2009 - 2010 (n = 300) | P value |
|---|---|---|---|
| Age-adjusted incidence (per 105 TEPa) | |||
| All | 11 | 27 | < 0.0001 |
| Hispanic | 10 | 27 | < 0.0001 |
| White | 10 | 23 | < 0.0001 |
| Black | 17 | 37 | 0.0020 |
| Age ≥ 35 years, n (%) | 16 (14.2) | 34 (11.3) | 0.5381 |
| Chronic co-morbidity, n (%)b | 32 (28.3) | 100 (33.3) | 0.3920 |
| Deyo-Charlson score | |||
| Mean (SD) | 0.38 (0.81) | 0.56 (0.97) | |
| Median (IQR) | 0 (0 - 1) | 0 (0 - 1) | 0.1173 |
| Obesity, n (%) | 1 (0.9) | 22 (7.3) | 0.0211 |
| Organ failures, n (%) | |||
| Respiratory | 65 (57.7) | 193 (64.3) | 0.2459 |
| Cardiovascular | 36 (31.9) | 181 (60.3) | < 0.0001 |
| Renal | 20 (18) | 94 (31) | 0.0099 |
| Hepatic | 4 (3.5) | 22 (7.3) | 0.2349 |
| Hematological | 28 (24.8) | 83 (27.7) | 0.6414 |
| Metabolic | 14 (12.4) | 68 (22.7) | 0.0281 |
| Neurological | 2 (1.8) | 29 (9.3) | 0.0152 |
| Number of organ failures | |||
| 1 | 73 (64.6) | 106 (35.3) | < 0.0001 |
| 2 | 30 (26.5) | 88 (29.3) | 0.6626 |
| 3 | 7 (6.2) | 59 (19.6) | 0.0015 |
| 4+ | 3 (2.7) | 47 (15.7) | 0.0006 |
| ICU admission, n (%) | 88 (77.9) | 270 (90) | 0.0020 |
| Procedures, n (%) | |||
| Mechanical ventilation | 45 (39.8) | 138 (46) | 0.3099 |
| Central venous catheterization | 31 (27.4) | 150 (50) | 0.0001 |
| Hemodialysis | 4 (3.5) | 18 (6) | 0.4552 |
| Hospital length of stay (days) | |||
| Mean (SD) | 14.7 (15.3) | 15.7 (21) | |
| Median (IQR) | 9 (6 - 19) | 9.5 (5.5 - 18) | 0.7939 |
| Hospital charges (dollars)c | |||
| Mean (SD) | 118,219 (145,240) | 191,503 (319,482) | |
| Median (IQR) | 64,034 (34,362 - 150,464) | 89,895 (43,614 - 218,357) | 0.0141 |
| Disposition, n (%) | |||
| Mortality | 11 (9.7) | 36 (12) | 0.6365 |
| Home | 80 (70.8) | 191 (63.7) | 0.2136 |
| Home care | 10 (8.8) | 30 (10) | 0.8683 |
| Another short-term facility | 8 (7.1) | 17 (5.7) | 0.5613 |
| Long-term care facility | 3 (2.7) | 14 (4.7) | 0.5224 |
| Otherd | 1 (0.9) | 10 (1.3) | 0.2412 |
| Mortality rate (per 105 TEP) | 1.1 | 3.3 | 0.0007 |
aTEP: total estimated pregnancy. bChronic co-morbidities included in the Deyo-Charlson index. cAdjusted for inflation (2,010 dollars). dInpatient rehabilitation, hospice, leaving against medical advice.