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. 2015 Feb 11;11(6):4190–4196. doi: 10.3892/mmr.2015.3333

Figure 4.

Figure 4

Tan IIA reduces BLM-induced upregulation in pulmonary iNOS expression and NO production in rats. (A) Representative images of immunohistochemical staining for iNOS protein in lung tissue samples, scale bars=20 μm. (B) iNOS protein expression in lung tissue specimens determined by western blot analysis. (C) Total NO levels, the sum of nitrate and nitrite in lung tissues quantified using Griess reaction method. Results are expressed as the mean ± standard deviation, n=3 per group. ###P<0.001 versus the control group; †††P<0.001 versus the Tan IIA group; **P<0.01, ***P<0.001 versus the BLM group. iNOS, inducible nitric oxide synthase; NO, nitric oxide. Tan IIA, Tanshinone IIA; BLM, bleomycin.