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. Author manuscript; available in PMC: 2015 Apr 13.
Published in final edited form as: Nature. 2014 Mar 2;509(7498):55–62. doi: 10.1038/nature13036

Figure 1. Development of broad neutralization by donor CAP256 and isolation of neutralizing antibodies.

Figure 1

(a) Timing of antibody isolation in relation to plasma neutralization titers against the primary infecting virus (PI), the superinfecting virus (SU), and a panel of 40 heterologous viruses (geometric mean titer shown). Percentage breadth (gray area), % of viruses neutralized with plasma ID50 >45. (b) Genetic characteristics and neutralization breadth and potency of the 12 isolated antibodies. Week of antibody isolation and V-gene mutation rates are indicated. Residues flanking the Kabat-defined CDR H3 sequences are shown in gray. Neutralization was assessed against a panel of 47 heterologous viruses. (c) Breadth and potency of antibody CAP256-VRC26.08 on a panel of 194 Env-pseudoviruses. Dendrogram shows phylogenetic relatedness of Env sequences in the panel.