Table 2. Body and tissue weights, blood pressure, biochemical and hematological data at the final time (12 weeks).
| Parameters | Sham group | CRF group |
|---|---|---|
| BW (Kg) | 0.45±0.02 | 0.36±0.01 *** |
| KW (g) | 1.22±0.03 | 1.65±0.04 *** |
| KW/BW (g/Kg) | 2.72±0.05 | 4.61±0.22 *** |
| HW (g) | 1.16±0.03 | 1.24 ± 0.07 |
| HW/BW (g/Kg) | 2.58±0.08 | 3.48±0.25 ** |
| LW (g/Kg) | 13.33±0.48 | 11.32±0.34 ** |
| LW/BW (g/Kg) | 29.61±0.65 | 31.43±0.71 * |
| SBP (mmHg) | 117.7 ± 1.15 | 134.1 ± 4.6 ** |
| DBP (mmHg) | 112.0 ± 0.58 | 111.5 ± 4.5 |
| MBP (mmHg) | 114.3 ± 1.45 | 121.3 ± 4.5 |
| HR (beats/min) | 360.7± 1.20 | 373.0 ± 9.2 |
| Glicose (mmol/L) | 9.46±0.31 | 8.66±0.60 |
| TGs (mmol/L) | 1.05±0.14 | 1.58±0.32 |
| Total-c (mmol/L)) | 1.25±0.06 | 2.44±0.54 * |
| CK (U/L) | 540.57±58.94 | 473.00±85.57 |
| ALT (U/L) | 35.17±2.21 | 42.00±18.53* |
| AST (U/L) | 80.57±7.84 | 139.43±70.70 |
| Bilirubin (μmol/L) | 8.04e-5±1.03e-5 | 1.03e-4±1.71e-5 |
| hsCRP (μg/mL) | 262.25±12.43 | 225.31±7.95 * |
| INF-γ (pg/mL) | 23.30±3.10 | 25.51±2.26 |
| TGF-β1 (ng/mL) | 75.74±5.62 | 84.13±3.85 |
| RBC (x 10 12 /L) | 7.94±0.08 | 6.53±0.43 ** |
| Ret (x10 9 /L) | 181.22±6.82 | 168.14±17.32 |
| MCV (fL) | 52.52±0.53 | 51.93±0.69 |
| MCH (pg) | 18.08±0.18 | 18.36±0.24 |
| MCHC (g/dL) | 34.60±0.08 | 35.37±0.19 ** |
| RDW (%) | 11.48±2.53 | 18.34±3.23 |
| PLT (x 10 9 /L) | 713.75±15.19 | 769.00±73.17 |
| PDW (%) | 16.34±0.18 | 16.44±0.20 |
| WBC (x 10 9 /L) | 1.78±0.30 | 5.01±1.76 |
| T Lymphocytes (%) | 57.20±1.36 | 54.67±2.91 |
| CD3 + CD4 + T cells (%) | 72.18±0.60 | 72.48±1.16 |
| CD3 + CD4 + CD25 + T cells (%) | 5.97±0.62 | 5.85±0.70 |
| CD3 + CD8 + T cells (%) | 24.16±1.34 | 28.17±2.17 |
| CD3 + CD8 + CD25 + T cells (%) | 0.40±0.04 | 0.63±0.01** |
Results are presented as mean ± SEM
*- p < 0.05
**- p < 0.01, and
***- p < 0.001 versus Sham group.
ALT—alanine transaminase, AST—aspartate transaminase; BW—body weight; CK—creatine kinase; DBP—diastolic blood pressure; Hb—hemoglobin; Hct—hematocrit; HR—heart rate; hsCRP—high-sensitive C reactive protein; HW—heart weight; IFN-γ - interferon γ; KW, kidney weight; LW, liver weight; MBP, mean blood pressure; MCH—mean cell hemoglobin; MCHC—mean cell hemoglobin concentration; MCV—mean cell volume; PDW—platelet distribution width; PLT—platelets; RBC—red blood cells; RDW—RBC distribution width; Ret—reticulocytes; SBP, systolic blood pressure; TGs—triglycerides; TGF-β1—transforming growth factor beta1; Total-c—total cholesterol; VEGF—vascular endothelial growth factor; WBC—white blood cells.