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The anti-proliferative effect of EPA and DHA in human non-small cell lung cancer A549 (COX-2 constitutively expressed) and H1299 (COX-2 lacking) cells. A. Exposure of A549 and H1299 cells to EPA for 72 hours produced an 8-fold stronger inhibition of cell proliferation to A549 cells than that in H1299 cells. B. Both A549 and H1299 cells were treated with DHA for 72 hrs. The anti-proliferative effect of DHA in A549 cells was only 5-fold stronger than that in H1299 cells.
