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. 2015 Apr 13;11(4):e1005151. doi: 10.1371/journal.pgen.1005151

Fig 2. Distribution of single cell mutation counts in mother cells.

Fig 2

(A) Mutation counts of mutator cells during yeast aging. Each lineage is plotted separately, except Lineage G, whose mother cell became multi-budded, producing two distinct lineages: G1 (blue) and G2 (light blue). The gap in Lineage F is due to sequencing failure of one of the daughter clones. Bottom right, all lineages are plotted together, each represented by a different line color. (B) The observed distribution (blue bars, combined data) of mutation counts is plotted against the predicted Poisson distribution based on the average genome-wide mutation rate (2.6 x 10-7 mutations/bp/cell division) (orange bars, Poisson Model) and a composite distribution resulting from two overlapping Poisson distributions with mutation rates of 4 x 10-8 (contributing 35%) and 4 x 10-7 (contributing 65%) mutations/bp/cell division (green bars, Two-Poisson Model).