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. 2015 Apr 15;26(8):1416–1427. doi: 10.1091/mbc.E14-11-1576

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© 2015 Cui et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 6: — MiR-1188 inhibited hepatoma tumor growth in vivo. (A) Hepa1-6 cells were injected subcutaneously into the left and right flanks of nude mice and the transplanted tumors harvested (n = 5). (B, C) The weight and volume of the harvested transplanted tumors. (D) The expression of miR-1188 in the tumors as found by qRT-PCR. (E) The expression of Bax, Bcl-2, and Sp1 in the tumors as revealed by immunoblot. (F) Inverse correlation between miR-1188 and Sp1 or Bcl-2 protein level in the tumors. Statistical analysis was performed using Pearson's R, and R and P values are as shown. (G) Immunohistochemistry showed the Sp1 expression (viewed by confocal microscopy). DAPI staining (blue) was used to visualize nuclei; Scale bars, 20 μm. (H) Schematic diagram showing the signaling network in which miR-1188 is involved. Error bars represent the SE obtained from three independent experiments; *p < 0.05, **p < 0.01, ***p < 0.001.