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. Author manuscript; available in PMC: 2015 Apr 13.
Published in final edited form as: Clin Chem. 2010 Nov 9;57(2):215–220. doi: 10.1373/clinchem.2010.149096

Table 1.

Randomized controlled trials on diabetes prevention.

Study No. of participants Study population Type of intervention Risk reduction Duration
Da Quing [Pan et al. (16)] 577 Chinese, mean age 45 years, BMI 26 kg/m2 Diet, exercise 31%–46% 6 years
STOP-NIDDMa [Chiasson etal. (21)] 1429 IGT adults, mean age 55 years, mean BMI 31 kg/m2 Acarbose 25% 3.3 years
Finnish DPS [Tuomilento et al. (18)] 522 IGT adults, mean age 55 years, mean BMI 31 kg/m2 Diet and exercise 58% 3.2 years
DPP [Knowler et al. (17)] 3234 IGT adults, mean age 51 years, mean BMI 34 kg/m2 Diet and exercise, or Metformin Metformin 31% 2.8 years
Lifestyle 58%
XENDOS [Orgerson et al. (22)] 3305 Swedish, BMI >30 kg/m2, mean age 43 years, 21% with IGT Orlistat + diet + exercise Entire group 37% 4 years
IGT subgroup 45%
DREAM [Hanley et al. (24)] 5269 IGT and/or IFG patients, mean age 54 years, BMI 30.9 kg/m2 Rosiglitazone 62% 3 years
a

STOP-NIDDM, Study to Prevent Non-Insulin-Dependent Diabetes Mellitus; DPS, Diabetes Prevention Study; XENDOS, XENical in the Prevention of Diabetes in Obese Subjects.