Table 6. Allelic and genotypic frequencies of 8 SNPs of KCNJ10 in the drug-responsive (n = 279) and drug-resistant GGEs patients (n = 204).
| Genotypes | Alleles | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug-responsive | Drug-resistant | GGEs A/B | |||||||||
| SNPs | Alleles | AA | AB | BB | AA | AB | BB | p-value | Control A/B | OR(95% CI) | p-value |
| rs1053074 | G/T | 27 | 85 | 91 | 31 | 115 | 133 | 0.71 | 139/267; 177/381 | 1.12[0.85–1.47] | 0.41 |
| rs1130183 | C/T | 202 | 0 | 1 | 278 | 0 | 0 | 0.24 | 404/2;556/0 | - | 0.1 |
| rs12729701 | A/G | 115 | 73 | 13 | 167 | 87 | 22 | 0.5 | 303/99 ;421/131 | 0.95[0.71–1.29] | 0.75 |
| rs12402969 | C/T | 3 | 32 | 169 | 2 | 27 | 249 | 0.096 | 38/370;31/525 | 1.73[1.06–2.85] | 0.026 |
| rs1186688 | T/C | 16 | 92 | 95 | 26 | 116 | 136 | 0.69 | 124/282;168/388 | 1.02[0.77–1.34] | 0.91 |
| rs1186685 | T/C | 4 | 76 | 124 | 17 | 99 | 161 | 0.09 | 84/324;133/421 | 0.82[0.60–1.12] | 0.21 |
| rs6690889 | T/C | 113 | 82 | 7 | 151 | 111 | 16 | 0.51 | 308/96;413/143 | 1.11[0.82–1.50] | 0.49 |
OR, odds ratio; CI, confidence interval; GGEs, genetic generalized epilepsies; OR, odds ratio estimated with binary logistic regression analysis and adjusted for age, age of epilepsy onset and gender.