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. 2015 Feb 5;19(4):826–835. doi: 10.1111/jcmm.12510

Fig 1.

Fig 1

Rosiglitazone dose-dependently suppresses HTL-induced oxidative stress and improves cell viabilities in cultured HUVECs. Cultured HUVECs were pre-treated with rosiglitazone (RSG, 0.001–1 mM) for 1 hr and then incubated with homocysteine thiolactone (HTL, 1 mM) for 24 hrs. (A) Cell viability was measured by MTT. (B) Intracellular ROS productions were detected by DHE/HPLC. (C) The concentration of soluble intercellular adhesion molecule 1 (sICAM-1) in culture medium was assayed by ELISA. All data were expressed as mean ± SEM. N is 3 in each group. *P < 0.05 versus Con, #P < 0.05 versus HTL alone. (D and E) Cultured HUVECs were treated with homocysteine (HCY, 1 mM) for 24 hrs. (D) Cell viability and (E) intracellular ROS productions were measured by MTT and DHE/HPLC respectively. Data were expressed as mean ± SEM. N is 3 in each group. *P < 0.05 versus Control.