Table 1. Study design.
| Groups | DNA Construct (μg) | Imiquimod (nmoles) | Resiquimod (nmoles) |
|---|---|---|---|
| Naïve | 0 | 0 | 0 |
| pVax1 | 100 | 0 | 0 |
| pA27L | 100 | 0 | 0 |
| pA27L + imiquimod | 100 | 50 | 0 |
| pA27L + resiquimod | 100 | 0 | 50 |
| pA27LOPT | 100 | 0 | 0 |
| pA27LOPT + imiquimod | 100 | 50 | 0 |
Experimental groups used on this study: 1. Naïve (negative control), 2. pVax1 (backbone control), 3. pA27L (100 μg DNA antigen), 4. pA27L+I (100 μg DNA antigen + 50 nmoles of imiquimod), 5. pA27L+R (100 μg DNA antigen + 50 nmoles of resiquimod), 6. pA27LOPT (100 μg DNA antigen) 7. pA27LOPT+I (100 μg DNA antigen + 50nmoles of imiquimod).