Table 2. Various incidence rates and effect sizes of cardiovascular disease and death by using univariable analysis.
.
| Variables | Total numbers | Person-years | Ischemic stroke | Total stroke | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Event (%) | Incidence rate (per 1000 PY) | Crude HR (95% CI) | P-value | Event (%) | Incidence rate (per 1000 PY) | Crude HR (95% CI) | P-value | |||
| Non-diabetis | 4915 | 46266 | 68 (1.38%) | 1.47 | 1 (Reference) | - | 120 (2.44%) | 2.59 | 1 (Reference) | - |
| Diabetis | 362 | 3125 | 20 (5.52%) | 6.4 | 4.23 (2.69–7.29) | <0.001 | 35 (9.67%) | 11.2 | 4.38 (3.00–6.38) | <0.001 |
| HbA1c (1% increment) | 5277 | 49391 | 88 (1.67%) | - | 1.47 (1.34–1.61) | <0.001 | 155 (2.94%) | - | 1.43 (1.33–1.54) | <0.001 |
| HbA1c group | ||||||||||
| <5.5% (36.5 mmol/mol) | 3899 | 36904 | 34 (0.87%) | 0.92 | 1 (Reference) | 70 (1.80%) | 1.90 | 1 (Reference) | - | |
| 5.5–6.4 (36.5–46.4) | 1022 | 9367 | 33 (3.23%) | 3.52 | 3.85 (2.39–6.22) | <0.001 | 52 (5.09%) | 5.55 | 2.95 (2.06–4.22) | <0.001 |
| 6.5–7.4 (47.5–57.4) | 173 | 1541 | 9 (5.20%) | 5.84 | 6.46 (3.10–13.5) | <0.001 | 13 (7.51%) | 8.44 | 4.52 (2.50–8.16) | <0.001 |
| ≥7.5 (58.5) | 183 | 1579 | 12 (6.56%) | 7.60 | 8.41 (4.36–16.3) | <0.001 | 20 (10.9%) | 12.7 | 6.79 (4.13–11.2) | <0.001 |
| Coronary heart disease | Total cardiovascular disease | |||||||||
| Non-diabetis | 4915 | 46507 | 34 (0.69%) | 0.73 | 1 (Reference) | - | 146 (2.97%) | 3.16 | 1 (Reference) | - |
| Diabetis | 362 | 3169 | 26 (7.18%) | 8.21 | 11.4 (6.86–19.1) | <0.001 | 55 (15.2%) | 17.9 | 5.78 (4.24–7.88) | <0.001 |
| HbA1c (1% increment) | 5277 | 49675 | 60 (1.14%) | - | 1.57 (1.43–1.72) | <0.001 | 201 (3.81%) | - | 1.47 (1.38–1.56) | <0.001 |
| HbA1c group | ||||||||||
| <5.5% (36.5 mmol/mol) | 3899 | 37026 | 18 (0.46%) | 0.49 | 1 (Reference) | 86 (2.21%) | 2.33 | 1 (Reference) | - | |
| 5.5–6.4 (36.5–46.4) | 1022 | 9488 | 20 (1.96%) | 2.11 | 4.36 (2.31–8.24) | <0.001 | 67 (6.56%) | 7.18 | 3.10 (2.25–4.27) | <0.001 |
| 6.5–7.4 (47.5–57.4) | 173 | 1556 | 5 (2.89%) | 3.21 | 6.73 (2.50–18.1) | <0.001 | 17 (9.83%) | 11.2 | 4.86 (2.89–8.18) | <0.001 |
| ≥7.5 (58.5) | 183 | 1605 | 17 (9.29%) | 10.6 | 22.3 (11.5–43.2) | <0.001 | 31 (16.9%) | 20.1 | 8.80 (5.84–13.3) | <0.001 |
| All-cause death | ||||||||||
| Non-diabetis | 4915 | 46619 | 231 (4.70%) | 4.96 | 1 (Reference) | - | ||||
| Diabetis | 362 | 3238 | 65 (18.0%) | 20.1 | 4.1 (3.11–5.39) | <0.001 | ||||
| HbA1c (1% increment) | 5277 | 49857 | 296 (5.61%) | - | 1.34 (1.26–1.42) | <0.001 | ||||
| HbA1c group | ||||||||||
| <5.5% (36.5 mmol/mol) | 3899 | 37087 | 147 (3.77%) | 3.96 | 1 (Reference) | - | ||||
| 5.5–6.4 (36.5–46.4) | 1022 | 9544 | 90 (8.81%) | 9.43 | 2.39 (1.84–3.10) | <0.001 | ||||
| 6.5–7.4 (47.5–57.4) | 173 | 1575 | 24 (13.9%) | 15.2 | 3.88 (2.52–5.97) | <0.001 | ||||
| ≥7.5 (58.5) | 183 | 1651 | 35 (19.1%) | 21.2 | 5.39 (3.73–7.80) | <0.001 | ||||