Table 2. Characteristics of study participants.
| Characteristics | Controls (n = 23) | FH (n = 30) | p-value a | FH ATX-(n = 14) | FH ATX+ (n = 16) | p-value b |
|---|---|---|---|---|---|---|
| Men/women | 8/15 | 12/18 | NS | 7/7 | 5/11 | NS |
| Age (years) | 47.0 ±10.1 | 45.5 ±9.1 | NS | 43.1 ±10.2 | 47.5 ±7.8 | NS |
| BMI (kg/m2) | 23.7 ±3.3 | 25.5 ±5.2 | NS | 25.1 ±4.2 | 25.9 ±5.9 | NS |
| Systolic bp (mm Hg) | 120.2 ±10.8 | 124.9 ±14.3 | NS | 122.4 ±13.7 | 127.1 ±14.8 | NS |
| Diastolic bp (mm Hg) | 74.6 ±6.7 | 77.4 ±6.5 | NS | 76.0 ±5.5 | 78.7 ±7.1 | NS |
| Platelets (109/L) | 239.8 ±50.7 | 248.6 ±60.1 | NS | 247 ±55.7 | 250 ± 65.4 | NS |
| Leukocytes (109/L) | 5.1 ± 1.2 | 5.4 ±1.9 | NS | 5.0 ±1.6 | 5.7 ±2.2 | NS |
| Monocytes (109/L) | 0.4 ±0.1 | 0.5 ±0.1 | NS | 0.4 ±0.1 | 0.5 ±0.2 | NS |
| Hemoglobin (mmol/L) | 8.7 ±0.6 | 9.0 ±0.8 | NS | 9.1 ±1.0 | 8.9 ±0.7 | NS |
| Total-C (mmol/L) | 5.1 ±0.7 | 9.1 ±1.8 | <0.0001 | 8.2 ±1.1 | 9.9 ±2.0 | <0.010 |
| LDL-C (mmol/L) | 2.9 ±0.5 | 7.0 ±1.8 | <0.0001 | 6.0 ±1.1 | 7.9 ±1.8 | 0.003 |
| HDL-C (mmol/L) | 1.7 ±0.4 | 1.5 ±0.4 | 0.014 | 1.5 ±0.5 | 1.4 ±0.4 | NS |
| oxLDL-C (Units/L) | 50.0 ±11.8 | 100.3 ± 24.2 | <0.0001 | 83.7 ±13.6 | 114.8 ±22.1 | 0.0001 |
| ApoB (g/L) | 0.8 ±0.1 | 1.7 ±0.4 | <0.0001 | 1.4 ±0.3 | 1.8 ±0.3 | 0.002 |
| Glucose (mmol/L) | 5.4 ±0.5 | 5.5 ±0.4 | NS | 5.5 ±0.4 | 5.5 ±0.4 | NS |
| ALT (U/L) | 19.0 (14.0–21.0) | 19.0 (17.0–34.0) | NS | 20.5 (18–32) | 18.5 (15.0–36.5) | NS |
| TG (mmol/L) | 1.0 (0.8–1.2) | 1.1 (0.8–1.8) | NS | 1.3 (0.7–1.8) | 1.1 (1.0–1.6) | NS |
| IL-6 (pg/ml) | 0.6 (0.0–0.7) | 0.8 (0.3–1.6) | 0.022 | 0.7 (0.3–1.0) | 1.0 (0.3–2.0) | NS |
| hs-CRP (μg/ml) | 1.0 (0.8–1.9) | 1.5 (0.6–4.2) | NS | 1.3 (0.4–3.9) | 1.9 (0.7–5.2) | NS |
| sCD36 (AU) | 0.4 (0.3–0.5) | 0.4 (0.3–0.5) | NS | 0.4 (0.2–0.5) | 0.4 (0.3–0.6) | NS |
| MMP-9 (pg/ml) | 0.9 (0.6–1.2) | 1.0 (0.7–2.1) | NS | 1.0 (0.7–1.8) | 1.1 (0.7–2.6) | NS |
| ICAM-1 (pg/ml) | 1.1 (1.0–1.5) | 1.3 (1.1–1.5) | NS | 1.3 ±0.2 | 1.4 ±0.5 | NS |
Normal and non-normally distributions are shown as the mean ±standard deviation and as the median (interquartile range), respectively.
aControls vs. FH subjects;
bFH subjects without ATX vs. FH subjects with ATX.
Abbreviations: BMI, Body mass index; ALT, Alanin-aminotransferase, TG, Triglycerides; ApoB, Apolipoprotein B; Total-C, Total cholesterol; LDL-C, LDL Cholesterol; HDL-C, HDL Cholesterol; oxLDL-C, oxidized LDL-C; bp, blood pressure; hs-CRP, High Sensitivity C-reactive Protein; IL-6, Interleukin 6; sCD36; soluble CD36, MMP-9, Matrix metalloproteinase 9; ICAM-1, Intercellular Adhesion Molecule 1; AU, arbitrary units; NS, non-significant.