Table 2. Associations between lifetime agoraphobia status at baseline and inflammatory measures at baseline and follow-up.

	Inflammatory markers at baseline			Inflammatory markers at follow-up
	No agoraphobia	Agoraphobia	p value	No agoraphobia	Agoraphobia	p value
CRP a (mg/l)	0.01±0.43 (n = 2766)	0.01±0.41 (n = 124)	0.851	0.06±0.40 (n = 2766)	0.14±0.43 (n = 124)	0.026
Interleukin-1β b (pg/ml)	47.8% (n = 2671)	46.3% (n = 121)	0.748	54.8% (n = 2671)	50.4% (n = 121)	0.343
Interleukin-6 a (pg/ml)	0.15±0.67 (n = 2671)	0.16±0.68 (n = 121)	0.929	0.47±0.77 (n = 2671)	0.56±0.78 (n = 121)	0.217
TNF-α a (pg/ml)	0.46±0.40 (n = 2671)	0.45±0.43 (n = 121)	0.834	0.65±0.47 (n = 2671)	0.74±0.43 (n = 121)	0.042
Adiponectin a (mg/l)	0.89±0.30 (n = 2559)	0.91±0.28 (n = 120)	0.610	0.58±0.30 (n = 2559)	0.56±0.34 (n = 120)	0.533
Composite score a , c	-0.07±2.02 (n = 2457)	-0.08±1.98 (n = 112)	0.963	-0.07±1.98 (n = 2457)	0.50±1.95 (n = 112)	0.003

Values for inflammatory measures are given as unadjusted log10-transformed means ± standard deviation, values for interleukin-1β are given as prevalence.

CRP, C-reactive protein; TNF, tumor necrosis factor.

^a Multiple regression with log10 transformed cytokine or CRP or adiponectin.

^b Logistic regression with interleukin-1β concentration dichotomized at the median.

^c Composite score of inflammatory markers includes CRP, interleukin-6 and TNF-α. Only participants who had data available for all three of these markers were included in these analyses.