Table 4. Associations between lifetime agoraphobia status at baseline and inflammatory measures (C-reactive protein) at follow-up, serially adjusted for covariates.

	CRP g (n = 2890)
	Model 1					Model 2					Model 3					Model 4					Model 5
	β	95CI			p	β	95CI			p	β	95CI			p	β	95CI			p	β	95CI			p
Agoraphobia at baseline	0.098	0.034	-	0.162	0.003	0.093	0.029	-	0.156	0.005	0.089	0.026	-	0.152	0.005	0.086	0.024	-	0.149	0.007	0.087	0.024	-	0.151	0.007
Length of follow-up a , years	-0.004	-0.036	-	0.028	0.813	-0.003	-0.034	-	0.029	0.866	-0.006	-0.037	-	0.025	0.691	-0.007	-0.038	-	0.024	0.672	-0.006	-0.038	-	0.025	0.686
CRP at baseline	0.115	0.107	-	0.122	<0.001	0.110	0.102	-	0.118	<0.001	0.098	0.090	-	0.106	<0.001	0.097	0.089	-	0.105	<0.001	0.097	0.089	-	0.105	<0.001
Age, years						0.004	0.002	-	0.005	<0.001	0.003	0.001	-	0.004	<0.001	0.003	0.002	-	0.005	<0.001	0.003	0.002	-	0.005	<0.001
Male						-0.019	-0.046	-	0.007	0.145	0.027	-0.002	-	0.056	0.066	0.027	-0.003	-	0.058	0.078	0.027	-0.004	-	0.058	0.090
Socioeconomic status b						-0.028	-0.039	-	-0.018	<0.001	-0.022	-0.032	-	-0.012	<0.001	-0.019	-0.029	-	-0.009	<0.001	-0.019	-0.030	-	-0.009	<0.001
Hypertension c											0.014	-0.019	-	0.048	0.405	0.013	-0.021	-	0.046	0.460	0.013	-0.021	-	0.046	0.460
Underweight											-0.180	-0.279	-	-0.081	<0.001	-0.188	-0.286	-	-0.089	<0.001	-0.187	-0.286	-	-0.089	<0.001
Overweight											0.089	0.059	-	0.120	<0.001	0.091	0.060	-	0.121	<0.001	0.091	0.060	-	0.122	<0.001
Obesity											0.123	0.076	-	0.171	<0.001	0.126	0.078	-	0.173	<0.001	0.125	0.078	-	0.173	<0.001
Glucose, fasting state mmol/L											-0.018	-0.032	-	-0.004	0.010	-0.019	-0.033	-	-0.005	0.008	-0.019	-0.033	-	-0.005	0.008
Total cholesterol/HDL-cholesterol ratio											0.027	0.014	-	0.040	<0.001	0.024	0.011	-	0.037	<0.001	0.024	0.011	-	0.037	<0.001
Former/current smokers																0.025	0.009	-	0.041	0.002	0.025	0.009	-	0.041	0.003
Low alcohol consumption																-0.038	-0.071	-	-0.005	0.023	-0.038	-0.071	-	-0.005	0.023
Moderate alcohol consumption																-0.047	-0.086	-	-0.007	0.020	-0.047	-0.086	-	-0.008	0.019
High alcohol consumption																-0.008	-0.052	-	0.035	0.715	-0.008	-0.052	-	0.036	0.717
Leisure physical activity d																-0.008	-0.034	-	0.018	0.553	-0.008	-0.034	-	0.018	0.543
Major depressive disorder																					0.002	-0.025	-	0.029	0.882
Other anxiety disorders e																					-0.003	-0.036	-	0.029	0.839
Drug dependence f																					-0.001	-0.081	-	0.078	0.977

Values for inflammatory measures are given as unadjusted log10-transformed means ± standard deviation, values for interleukin-1β are given as prevalence.

HDL, high-density lipoprotein; CRP, C-reactive protein; TNF, tumor necrosis factor; OR, odds ratio; 95CI, 95% confidence interval.

^a Duration between somatic evaluation at baseline and somatic evaluation at follow-up.

^b A value of “3” represents an SES of III (middle class) on the Hollingshead Scale.

^c Systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg.

^d Physically active at least or more than 20 minutes twice a week.

^e Generalized anxiety disorder, panic disorder, posttraumatic stress disorder, and/or social phobia.

^f Marijuana, cocaine, solvent, hallucinogen, stimulant, sedative or/and narcotic dependence.

^g Multiple regression with log10-transformed cytokine or CRP or adiponectin.

^h Logistic regression with interleukin-1β concentration dichotomized at the median.

ⁱ Composite score of inflammatory markers includes CRP, interleukin-6 and TNF-α. Only participants who had data available for all three of these markers were included in these analyses.