Table 6. Associations between lifetime agoraphobia status at baseline and inflammatory measures (interleukin-6) at follow-up, serially adjusted for covariates.

	Interleukin-6 g (n = 2792)
	Model 1					Model 2					Model 3					Model 4					Model 5
	β	95CI			p	β	95CI			p	β	95CI			p	β	95CI			p	β	95CI			p
Agoraphobia at baseline	0.093	-0.044	-	0.230	0.184	0.105	-0.033	-	0.242	0.135	0.101	-0.037	-	0.238	0.152	0.095	-0.043	-	0.232	0.178	0.102	-0.038	-	0.241	0.153
Length of follow-up a , years	-0.012	-0.084	-	0.059	0.735	-0.016	-0.087	-	0.056	0.667	-0.023	-0.094	-	0.049	0.534	-0.024	-0.095	-	0.048	0.520	-0.028	-0.099	-	0.044	0.449
Interleukin-6 at baseline	0.003	0.002	-	0.003	<0.001	0.003	0.002	-	0.003	<0.001	0.003	0.002	-	0.003	<0.001	0.003	0.002	-	0.003	<0.001	0.003	0.002	-	0.003	<0.001
Age, years						-0.001	-0.004	-	0.002	0.495	-0.001	-0.004	-	0.002	0.520	-0.001	-0.004	-	0.002	0.543	-0.001	-0.005	-	0.002	0.522
Male						-0.061	-0.118	-	-0.005	0.034	-0.033	-0.097	-	0.031	0.309	-0.041	-0.108	-	0.026	0.228	-0.024	-0.092	-	0.045	0.499
Socioeconomic status b						-0.012	-0.034	-	0.010	0.286	-0.011	-0.033	-	0.012	0.363	-0.009	-0.032	-	0.014	0.444	-0.008	-0.031	-	0.015	0.487
Hypertension c											-0.006	-0.080	-	0.067	0.867	-0.003	-0.077	-	0.071	0.938	-0.003	-0.076	-	0.071	0.942
Underweight											-0.121	-0.344	-	0.102	0.288	-0.134	-0.357	-	0.090	0.241	-0.138	-0.361	-	0.085	0.225
Overweight											-0.031	-0.097	-	0.036	0.365	-0.027	-0.094	-	0.040	0.424	-0.026	-0.093	-	0.041	0.446
Obesity											0.004	-0.094	-	0.102	0.936	0.011	-0.088	-	0.109	0.835	0.012	-0.087	-	0.111	0.806
Glucose, fasting state mmol/L											-0.013	-0.043	-	0.018	0.412	-0.012	-0.043	-	0.018	0.426	-0.013	-0.043	-	0.017	0.406
Total cholesterol/HDL-cholesterol ratio											0.042	0.014	-	0.071	0.003	0.039	0.010	-	0.068	0.008	0.040	0.011	-	0.068	0.007
Former/current smokers																0.035	-0.001	-	0.071	0.055	0.034	-0.002	-	0.070	0.063
Low alcohol consumption																-0.025	-0.098	-	0.048	0.501	-0.023	-0.096	-	0.050	0.535
Moderate alcohol consumption																-0.048	-0.134	-	0.039	0.282	-0.051	-0.137	-	0.036	0.253
High alcohol consumption																-0.039	-0.135	-	0.058	0.429	-0.041	-0.137	-	0.055	0.406
Leisure physical activity d																0.024	-0.034	-	0.083	0.417	0.024	-0.034	-	0.083	0.412
Major depressive disorder																					-0.061	-0.120	-	-0.002	0.045
Other anxiety disorders e																					-0.013	-0.084	-	0.059	0.729
Drug dependence f																					0.147	-0.036	-	0.331	0.115

Values for inflammatory measures are given as unadjusted log10-transformed means ± standard deviation, values for interleukin-1β are given as prevalence.

HDL, high-density lipoprotein; CRP, C-reactive protein; TNF, tumor necrosis factor; OR, odds ratio; 95CI, 95% confidence interval.

^a Duration between somatic evaluation at baseline and somatic evaluation at follow-up.

^b A value of “3” represents an SES of III (middle class) on the Hollingshead Scale.

^c Systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg.

^d Physically active at least or more than 20 minutes twice a week.

^e Generalized anxiety disorder, panic disorder, posttraumatic stress disorder, and/or social phobia.

^f Marijuana, cocaine, solvent, hallucinogen, stimulant, sedative or/and narcotic dependence.

^g Multiple regression with log10 transformed cytokine or CRP or adiponectin.

^h Logistic regression with interleukin-1β concentration dichotomized at the median.

ⁱ Composite score of inflammatory markers includes CRP, interleukin-6 and TNF-α. Only participants who had data available for all three of these markers were included in these analyses.