Table 5. Out of range and frequency of adverse events in the Kisumu Adult cohort obtained from comparison with values from locally-established reference intervals, DAIDS and North American derived MGH values.

							Out of range comparison
		This Study		Local reference [15]			MGH-USA [9]			2004 DAIDS [17]
Parameter	Gender	95% reference interval	n	95% reference interval	n	%	95% reference interval	n	%	Cut-off	N	%
Hemoglobin (g/dL)	Female	9.0–14.9	322	8.0–14.2	4	1.2	12–16	85	26.4	>10.9	40	12.4
	Male	12.6–17.2	389	11.4–16.9	4	1.0	13.5–17.5	28	7.2	>10.9	3	0.8
Hematocrit (%)	Female	28.6–44.2	322	23.2–44.3	2	0.6	36–46	83	25.8
	Male	38.1–51.6	389	32.6–51.5	3	0.8	41–53	37	9.5
MCV (%)	Female	59.3–93.2	322	60–94	12	3.7	80–100	153	47.5
	Male	67.4–93.6	389	55–98	3	0.8	80–100	103	26.5
WBC (x10 9 /L)	Female	3.7–9.1	322	3.3–9.7	8	2.5	4.5–11.0	37	11.5	>2.5	1	0.3
	Male	3.3–9.6	389	2.5–7.4	0	0	4.5–11.0	82	21.1	>2.5	0	0
RBC (x10 12 /L)	Female	4.0–5.8	322	3.4–5.7	1	0.3	4.0–5.2	7	2.2
	Male	4.6–6.6	389	4.3–6.5	2	0.5	4.2–6.3	2	0.5
Lymphocytes (x10 9 /L)	Female	1.4–3.8	322	1.3–3.8	7	2.2	1.0–4.8	0	0
	Male	1.2–3.4	389	1.0–3.5	4	1.0	1.0–4.8	4	1.0
Neutrophils (x10 9 /L)	Female	1.3–5.0	322	1.3–3.8	10	3.1	1.8–7.7	0	0	>1.3	10	3.3
	Male	1.3–5.2	389	0.8–3.9	0	0	1.8–7.7	4	1.0	>1.3	13	4.0
PLT (x10 9 /L)	Female	147–454	322	88–439	1	0.3	150–350	12	3.7	≥125	4	1.2
	Male	126–356	389	102–307	4	1.0	150–350	30	7.7	≥125	8	2.1
Eosinophils (10 3 cells/μl)	Female	0.04–1.2	322	0–1.3	7	2.2	0–0.5	52	16.1
	Male	0.04–1.6	389	0–1.7	5	1.3	0–0.5	77	19.8
ALT (μ/L)	Female	7.2–34.1	322	0–61.3	1	0.3	0–35	7	2.2	<76.6	0	0
	Male	8.4–54.7	389	0–80.6	4	1.0	0–35	39	10.0	<100.8	2	0.5
BUN (mmol/L)	Female	1.2–4.1	322	1.4–4.5	23	7.1	3.6–7.1	305	94.7
	Male	1.5–5.0	389	1.8–5.3	32	8.2	3.6–7.1	324	83.3
Creatinine (μmol/L)	Female	57–100	322	0–96.8	18	5.6	0–133	0	0	<106.5	4	1.2
	Male	69–123	389	0–137.8	2	0.5	0–133	2	0.5	<151.6	1	0.3