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. 2015 Apr 13;10(4):e0123009. doi: 10.1371/journal.pone.0123009

Fig 3. Leishmania infantum naturally infected dogs present increased levels of immunoglobulins.

Fig 3

Leishmania-specific total IgG (A and C) and total IgM (B) levels in sera from noninfected dogs (control, n = 15) and from naturally infected dogs with either low (lowP, n = 46) or high (highP, n = 42) parasite load in spleen. Optical density of serum samples were determined by ELISA (A and B) using crude protein derived from L. infantum promastigotes IOC/L3128 (MCAN/BR/2009/BOB-FÍGADO). Reflectance values were determined by the rapid immunocromatographic test (Dual Path Platform, DPP, BioManguinhos). Horizontal bars indicate mean values. The dashed line indicates the cut-off, 0.549 for IgG and 0.645 for IgM. (***) p < 0.001; (**) p < 0.0002 indicate statistically significant differences, Mann Whitney test.