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. 2015 Apr 13;11(4):e1004831. doi: 10.1371/journal.ppat.1004831

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© 2015 Collins, Speck

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 8 — IL21R^+/+/IL21R^-/- mixed bone marrow chimeric mice were infected intranasally with 1,000 pfu of MHV68-H2bYFP and spleens were harvested at the indicated days. (A) Total number of Ly5.1⁺ IL21R^+/+ and Ly5.2⁺ Il21R^-/- splenocytes harvested. (B) Percentage of B cells with a germinal center phenotype. Cells were gated on Ly5.1⁺ or Ly5.2⁺, B220⁺ CD3^-, CD4^-, CD8^- and germinal center B cells were defined as CD95^hi GL7^hi. (C) Percentage of splenocytes with a plasma cell phenotype. Cells were gated on CD3^-, CD4^-, CD8^- and plasma cells were defined as B220^neg-lo CD138^hi. (D) Percentage of splenocytes that were MHV68 infected (YFP+). Cells were gated on CD3^-, CD4^-, CD8^- splenocytes. **, p = 0.0029; ****,p<0.0001.