Table 1. Association of rs870142 (T>C), rs16835979 (A>C) and rs6824295 (T>C) polymorphisms with ASD.
| SNP | Genotype frequency n (%) | Allele frequency n (%) | OR(95%CI) | P | P perm | P FDR-BH | |||
|---|---|---|---|---|---|---|---|---|---|
| rs870142 | CC | TC | TT | T | C | ||||
| Cases(190) | 77(40.5) | 83(43.7) | 30(15.8) | 143(37.6) | 237(62.4) | 2.826(1.451–5.505) a | 0.002 | 0.003 | 0.006 |
| Controls(225) | 110(48.9) | 101(44.9) | 14(6.2) | 129(28.7) | 321(71.3) | 1.501(1.122–2.009) b | 0.006 | 0.006 | 0.018 |
| rs16835979 | CC | AC | AA | A | C | ||||
| Cases (190) | 79(41.6) | 80(42.1) | 31(16.3) | 142(37.4) | 238(62.6) | 2.730(1.425–5.228) a | 0.002 | 0.003 | 0.003 |
| Controls(225) | 111(49.3) | 99(44.0) | 15(6.7) | 129(28.7) | 321(71.3) | 1.485(1.109–1.987) b | 0.008 | 0.009 | 0.012 |
| rs6824295 | CC | TC | TT | T | C | ||||
| Cases (190) | 72(40.7) | 86(42.2) | 32(17.1) | 150(39.5) | 230(60.5) | 2.478(1.328–4.623) a | 0.003 | 0.004 | 0.003 |
| Controls (225) | 98(50.0) | 110(42.0) | 17(8.0) | 144(32.0) | 306(68.0) | 1.386(1.042–1.844) b | 0.025 | 0.028 | 0.025 |
a the value of OR (95%CI) in the recessive genetic model.
b the value of OR (95%CI) in the additive genetic model. Pperm denoted empirical significance values on the basis of 10,000 permutations in the recessive and additive genetic models, respectively. PFDR-BH denoted the P-value after performing multiple testing corrections with FDR-BH method.