Table 3. Haplotype main effect and conditional haplotype-based analysis tests (MHF>0.01).
| Haplotype | S1 | S2 | S3 | F(case/control) | χ2 | OR (95%CI) | Asymptotic P-value | P FDR-BH |
|---|---|---|---|---|---|---|---|---|
| H1 | T | A | T | 0.362/0.267 | 8.424 | 1.540 (1.030–2.380) | 0.004 | 0.016 |
| H2 | C | C | T | 0.031/0.047 | 1.386 | 0.239 | 0.319 | |
| H3 | C | A | C | 0.010/0.012 | 0.260 | 0.610 | 0.610 | |
| H4 | C | C | C | 0.599/0.674 | 4.892 | 0.720 (0.490–0.910) | 0.027 | 0.054 |
| Pcond | 0.85 | 0.57 | 0.25 |
MHF: minor haplotype frequency; H1, H2, H3, H4 represented haplotype1, haplotype2, haplotype3, haplotype4, respectively. S1, S2, S3 represented SNP rs870142, rs16835979, rs6824295, respectively. F(case/control) represented haplotype frequency in the cases and controls. OR (95%CI) and asymptotic P-value denoted haplotypic odds ratio and P-value in the haplotype association analysis. PFDR-BH denoted the P-value after performing multiple testing corrections with FDR-BH method. Pcond denoted P-value in the conditional test which determined whether the haplotype association could be attributive to that single SNP.